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The Spitz nevus has a tendency to emerge abruptly and proliferate swiftly. In terms of its histological composition, it encompasses numerous traits that could potentially lead to misdiagnosis as a malignant growth. It is noteworthy that this reddish to brownish, dome-like papule, commonly manifesting on the facial region or extremities, was formerly designated as benign juvenile melanoma. Here, the term "benign" serves as the pivotal identifier.
A Spitz nevus commonly presents itself as a pink, elevated protrusion, though it may also manifest in hues of blue, brown, or black, either as a flat spot or a raised bump. Initially, upon its emergence, a Spitz nevus tends to undergo a period of growth spanning a couple of months. Subsequent to this growth phase, the nevus ought to cease expanding and maintain its original dimensions, form, and coloration.
Both varieties of nevi exhibit symmetry and a core devoid of distinct structural patterns. Nevertheless, an examination of dermatoscopic attributes through statistical methods unveiled that pigmented Spitz nevi are more inclined to display centrally positioned clusters (globules) along with a brown center lacking discernible structures, in comparison to Reed nevi.
The aforementioned mole can potentially cause irritation, emit blood, or feature a discharge-emitting orifice. Nevertheless, it's noteworthy that these manifestations are not prevalent, as a majority of individuals harboring a Spitz nevus remain devoid of any discernible symptoms.
Medical differential diagnosis considerations
The typical differential diagnoses for CSN and ASTs encompass a spectrum of congenital, acquired, and dysplastic forms of melanocytic nevi, in addition to a diverse array of non-pigmented skin conditions, which may include pyogenic granulomas, hemangiomas, angiofibromas, keloids, and xanthogranulomas.
The typical progression of Classic Spitz nevi involves an initial growth phase spanning a few months, followed by a gradual diminishing over several years. Regular medical observation may suffice for these nevi. However, in adult cases and those that exhibit potential connections to melanoma, like pigmented and unusual Spitz tumors, surgical excision from the skin is generally recommended. February 1st, 2018.
Both Spitzoid melanoma and a Spitz nevus exhibit striking similarities in their visual appearance. Nevertheless, it's crucial to recognize that a spitzoid melanoma constitutes a cancerous entity. Characterized by the unchecked proliferation of cancerous cells, it poses the risk of dissemination to various regions within the body. Conversely, a Spitz nevus is benign in nature, representing a mole that frequently displays hues of pink or red, distinct from the typical brown or black tones observed in other moles.
Despite the fact that Spitz nevus is categorized as a benign melanocytic neoplasm, its histological characteristics are considered 'unusual' and may pose challenges in differentiating it from melanomas. 22nd April, 2016
Although they typically manifest as solitary formations, there are instances where they can emerge in clusters or spread in a disseminated pattern. The exceptionally infrequent occurrence of Spitz nevi manifesting abruptly in a disseminated manner is referred to as eruptive Spitz nevi, primarily affecting individuals ranging from young adulthood to middle age.
Based on our understanding, Spitz nevi are typically associated with the reticular dermis, in contrast to Reed nevi, which do not demonstrate such an association. Additionally, the ability of pigmented Spitz and Reed nevi to produce melanin serves as a distinguishing factor, directly correlating with their dermatopathologic and dermatoscopic characteristics. January 31st, 2012
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